If you can run them past other enemies, that'll provoke opportunity attacks that, again, will transfer to the boss. When it's your turn again, have your character with Shackles of Pain run around like a headless chicken (preferably through fire and poison to transfer even more damage). It'll transfer an absolutely hideous amount of damage through Shackles of Pain, and probably kill the boss. Now, every step that character takes will do damage that is channeled directly to the boss. Reduce the boss's armor points and have one character cast Shackles of Pain on it, then have your Scoundrel attack that character with Rupture Tendons and your Necromancer cast Living on the Edge so that they'll stay alive.
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Living on the Edge prevents a character's health from dropping below 1 HP for two rounds. Shackles of Pain forges a link between the caster and a target enemy so that any damage the caster receives is transferred to the victim. You'll need a character with Necromancer skills Shackles of Pain (sold by Mona in Fort Joy Ghetto at level four) and Living on the Edge (drops randomly around level 11 or is a starter skill for Witch mercenaries hired in act two). The Chicken Combo has quickly become a community favorite, but redditor Ulminati has taken the idea in a bizarre direction: What if you cast Rupture Tendons on yourself? This spell turns foes into squabbling chickens that run around aimlessly for two turns. While you have to wait until level four to get Rupture Tendons, characters who specialize in Polymorph skills can pick up Chicken Claw from Doctor Leste in Fort Joy at any time (Shadowblade and Metamorph classes start with Chicken Claw, and can pick up Rupture Tendons later with two points in Scoundrel). The first method is called the Chicken Combo. Normally you'd use it on an enemy and hope they'll take a step or two after, but some clever players have found a way to make Rupture Tendons deal incredible amounts of damage.
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Once an enemy is hit with Rupture Tendons, every step they take causes additional piercing damage. It's a Scoundrel skill purchased from Hilde in Fort Joy once you reach level four. Right now, two popular methods involve a skill called Rupture Tendons. If you're having trouble getting started, check out our beginner's guide (opens in new tab) that'll make the first 20 hours a little less bumpy. With more robust combat and a sprawling story, Divinity: Original Sin 2 is an even more complex RPG that the first.